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SITE009 (AUS)

AUS PI: Dr. Novak activated KRI 0.84
Patients
30
Active (enrolled/consented)
0
Withdrawn
4
Serious AEs
14
Open QA findings
7
Aged data queries
0

Studies & contracts total budget 330000.00 USD

A Phase III, Randomized, Double-Blind Study of Torivumab Plus Chemotherapy Versus Placebo Plus Chemotherapy in Previously Untreated Advanced Non-Small Cell Lung Cancer
Phase III study completed contract executed 330000 USD

Patients first 30

RefStatusConsentedStudy
SITE009-0016 withdrawn 2022-03-13 A Phase III, Randomized, Double-Blind Study of Torivumab Plus Chemotherapy Versus Placebo Plus Chemotherapy in Previously Untreated Advanced Non-Small Cell Lung Cancer
SITE009-0036 completed 2022-04-12 A Phase III, Randomized, Double-Blind Study of Torivumab Plus Chemotherapy Versus Placebo Plus Chemotherapy in Previously Untreated Advanced Non-Small Cell Lung Cancer
SITE009-0040 completed 2022-04-06 A Phase III, Randomized, Double-Blind Study of Torivumab Plus Chemotherapy Versus Placebo Plus Chemotherapy in Previously Untreated Advanced Non-Small Cell Lung Cancer
SITE009-0055 withdrawn 2022-04-28 A Phase III, Randomized, Double-Blind Study of Torivumab Plus Chemotherapy Versus Placebo Plus Chemotherapy in Previously Untreated Advanced Non-Small Cell Lung Cancer
SITE009-0070 withdrawn 2022-05-22 A Phase III, Randomized, Double-Blind Study of Torivumab Plus Chemotherapy Versus Placebo Plus Chemotherapy in Previously Untreated Advanced Non-Small Cell Lung Cancer
SITE009-0073 completed 2022-05-19 A Phase III, Randomized, Double-Blind Study of Torivumab Plus Chemotherapy Versus Placebo Plus Chemotherapy in Previously Untreated Advanced Non-Small Cell Lung Cancer
SITE009-0081 completed 2022-05-31 A Phase III, Randomized, Double-Blind Study of Torivumab Plus Chemotherapy Versus Placebo Plus Chemotherapy in Previously Untreated Advanced Non-Small Cell Lung Cancer
SITE009-0089 completed 2022-06-16 A Phase III, Randomized, Double-Blind Study of Torivumab Plus Chemotherapy Versus Placebo Plus Chemotherapy in Previously Untreated Advanced Non-Small Cell Lung Cancer
SITE009-0091 completed 2022-06-15 A Phase III, Randomized, Double-Blind Study of Torivumab Plus Chemotherapy Versus Placebo Plus Chemotherapy in Previously Untreated Advanced Non-Small Cell Lung Cancer
SITE009-0098 completed 2022-06-25 A Phase III, Randomized, Double-Blind Study of Torivumab Plus Chemotherapy Versus Placebo Plus Chemotherapy in Previously Untreated Advanced Non-Small Cell Lung Cancer
SITE009-0120 completed 2022-07-19 A Phase III, Randomized, Double-Blind Study of Torivumab Plus Chemotherapy Versus Placebo Plus Chemotherapy in Previously Untreated Advanced Non-Small Cell Lung Cancer
SITE009-0143 completed 2022-08-10 A Phase III, Randomized, Double-Blind Study of Torivumab Plus Chemotherapy Versus Placebo Plus Chemotherapy in Previously Untreated Advanced Non-Small Cell Lung Cancer
SITE009-0145 withdrawn 2022-08-06 A Phase III, Randomized, Double-Blind Study of Torivumab Plus Chemotherapy Versus Placebo Plus Chemotherapy in Previously Untreated Advanced Non-Small Cell Lung Cancer
SITE009-0162 completed 2022-09-15 A Phase III, Randomized, Double-Blind Study of Torivumab Plus Chemotherapy Versus Placebo Plus Chemotherapy in Previously Untreated Advanced Non-Small Cell Lung Cancer
SITE009-0168 completed 2022-09-18 A Phase III, Randomized, Double-Blind Study of Torivumab Plus Chemotherapy Versus Placebo Plus Chemotherapy in Previously Untreated Advanced Non-Small Cell Lung Cancer
SITE009-0182 completed 2022-09-23 A Phase III, Randomized, Double-Blind Study of Torivumab Plus Chemotherapy Versus Placebo Plus Chemotherapy in Previously Untreated Advanced Non-Small Cell Lung Cancer
SITE009-0191 completed 2022-10-13 A Phase III, Randomized, Double-Blind Study of Torivumab Plus Chemotherapy Versus Placebo Plus Chemotherapy in Previously Untreated Advanced Non-Small Cell Lung Cancer
SITE009-0255 completed 2022-12-18 A Phase III, Randomized, Double-Blind Study of Torivumab Plus Chemotherapy Versus Placebo Plus Chemotherapy in Previously Untreated Advanced Non-Small Cell Lung Cancer
SITE009-0259 completed 2023-01-02 A Phase III, Randomized, Double-Blind Study of Torivumab Plus Chemotherapy Versus Placebo Plus Chemotherapy in Previously Untreated Advanced Non-Small Cell Lung Cancer
SITE009-0268 completed 2023-01-17 A Phase III, Randomized, Double-Blind Study of Torivumab Plus Chemotherapy Versus Placebo Plus Chemotherapy in Previously Untreated Advanced Non-Small Cell Lung Cancer
SITE009-0351 completed 2023-04-14 A Phase III, Randomized, Double-Blind Study of Torivumab Plus Chemotherapy Versus Placebo Plus Chemotherapy in Previously Untreated Advanced Non-Small Cell Lung Cancer
SITE009-0353 completed 2023-04-25 A Phase III, Randomized, Double-Blind Study of Torivumab Plus Chemotherapy Versus Placebo Plus Chemotherapy in Previously Untreated Advanced Non-Small Cell Lung Cancer
SITE009-0354 completed 2023-04-20 A Phase III, Randomized, Double-Blind Study of Torivumab Plus Chemotherapy Versus Placebo Plus Chemotherapy in Previously Untreated Advanced Non-Small Cell Lung Cancer
SITE009-0373 completed 2023-05-04 A Phase III, Randomized, Double-Blind Study of Torivumab Plus Chemotherapy Versus Placebo Plus Chemotherapy in Previously Untreated Advanced Non-Small Cell Lung Cancer
SITE009-0413 completed 2023-07-25 A Phase III, Randomized, Double-Blind Study of Torivumab Plus Chemotherapy Versus Placebo Plus Chemotherapy in Previously Untreated Advanced Non-Small Cell Lung Cancer
SITE009-0414 completed 2023-07-29 A Phase III, Randomized, Double-Blind Study of Torivumab Plus Chemotherapy Versus Placebo Plus Chemotherapy in Previously Untreated Advanced Non-Small Cell Lung Cancer
SITE009-0415 completed 2023-07-30 A Phase III, Randomized, Double-Blind Study of Torivumab Plus Chemotherapy Versus Placebo Plus Chemotherapy in Previously Untreated Advanced Non-Small Cell Lung Cancer
SITE009-0428 completed 2023-08-17 A Phase III, Randomized, Double-Blind Study of Torivumab Plus Chemotherapy Versus Placebo Plus Chemotherapy in Previously Untreated Advanced Non-Small Cell Lung Cancer
SITE009-0439 completed 2023-09-08 A Phase III, Randomized, Double-Blind Study of Torivumab Plus Chemotherapy Versus Placebo Plus Chemotherapy in Previously Untreated Advanced Non-Small Cell Lung Cancer
SITE009-0442 completed 2023-09-10 A Phase III, Randomized, Double-Blind Study of Torivumab Plus Chemotherapy Versus Placebo Plus Chemotherapy in Previously Untreated Advanced Non-Small Cell Lung Cancer

Luna participants (0)

No participants at this site use Luna yet.

Safety 177 AEs · 14 serious

serious SITE009-0016 assessed

Grade 4 Asthenia — outcome: RECOVERED/RESOLVED; onset 2022-10-09 (study day 204); relationship: not assessed; serious criteria: life-threatening

serious SITE009-0040 assessed

Grade 3 Anaemia — outcome: RECOVERED/RESOLVED; onset 2022-05-25 (study day 29); relationship: not assessed; serious criteria: hospitalization

serious SITE009-0070 assessed

Grade 3 Alopecia — outcome: RECOVERED/RESOLVED; onset 2023-12-27 (study day 574); relationship: not assessed; serious criteria: hospitalization

serious SITE009-0089 assessed

Grade 4 Thrombocytopenia — outcome: RECOVERED/RESOLVED; onset 2024-03-31 (study day 645); relationship: not assessed; serious criteria: life-threatening

serious SITE009-0089 assessed

Grade 3 Nausea — outcome: RECOVERED/RESOLVED; onset 2024-07-06 (study day 742); relationship: not assessed; serious criteria: hospitalization

serious SITE009-0091 assessed

Grade 3 Stomatitis — outcome: RECOVERED/RESOLVED; onset 2024-02-27 (study day 611); relationship: not assessed; serious criteria: hospitalization

serious SITE009-0351 assessed

Grade 4 Fatigue — outcome: RECOVERED/RESOLVED; onset 2023-12-26 (study day 242); relationship: not assessed; serious criteria: life-threatening

serious SITE009-0353 assessed

Grade 3 Peripheral neuropathy — outcome: RECOVERED/RESOLVED; onset 2023-10-22 (study day 174); relationship: Y; serious criteria: hospitalization

QA findings 7 open

resolved minor Protocol deviation

OTHER: Sample not stored at correct temperature (excursion <2 hr) (subject SITE009-0016, 2022-05-12)

open major Protocol deviation

OTHER: Randomisation stratum mis-assigned (subject SITE009-0036, 2022-12-01)

resolved minor Protocol deviation

ASSESSMENT OUTSIDE PROTOCOL WINDOW: Visit outside ±3 day window (subject SITE009-0070, 2023-07-22)

resolved minor Protocol deviation

ASSESSMENT OUTSIDE PROTOCOL WINDOW: Visit outside ±5 day window (subject SITE009-0089, 2025-01-25)

resolved minor Protocol deviation

ASSESSMENT OUTSIDE PROTOCOL WINDOW: Visit outside ±3 day window (subject SITE009-0145, 2022-08-30)

resolved minor Protocol deviation

ASSESSMENT OUTSIDE PROTOCOL WINDOW: Visit outside ±5 day window (subject SITE009-0168, 2022-10-23)

resolved minor Protocol deviation

OTHER: Sample not stored at correct temperature (excursion <2 hr) (subject SITE009-0168, 2024-05-02)

resolved minor Protocol deviation

LATE ASSESSMENT: Safety assessment delayed (subject SITE009-0182, 2022-11-12)

open major Protocol deviation

MISSED REQUIRED EFFICACY ASSESSMENT: Two consecutive scheduled tumour assessments missed (subject SITE009-0182, 2025-01-05)

open major Protocol deviation

PROHIBITED CONCOMITANT MEDICATION: Subject received live attenuated vaccine during treatment period (subject SITE009-0268, 2023-02-06)

open major Protocol deviation

DOSE MODIFICATION ERROR: Dose held longer than protocol-permitted 6 weeks (subject SITE009-0268, 2023-05-07)

resolved minor Protocol deviation

ASSESSMENT OUTSIDE PROTOCOL WINDOW: Visit outside ±3 day window (subject SITE009-0268, 2023-05-09)

Monitoring visits (1)

on_site 2026-09-01 risk-flagged

Proposed by risk-based monitoring (score 0.84). Pending CRA confirmation.

Payments (0)

No payments on file.