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Trials 21
A Multicenter, Randomized, Open-Label Phase 2b Study to Investigate the Preliminary Efficacy and Safety of INNO-206 (Doxorubicin-EMCH) Compared to Doxorubicin in Subjects With Metastatic, Locally Advanced, or Unresectable Soft Tissue Sarcoma
Phase II
Soft-tissue sarcoma
completed
A Phase 1 Study to Evaluate Intratumoral Doxorubicin Exposure Following Administration of Aldoxorubicin or Doxorubicin
Phase I
Soft-tissue sarcoma
startup
A Phase III, Randomized, Double-Blind Study of Torivumab Plus Chemotherapy Versus Placebo Plus Chemotherapy in Previously Untreated Advanced Non-Small Cell Lung Cancer
Phase III
Non-Small Cell Lung Cancer
active
ADCElerate1: ADCE-D01 (uPARAP ADC) in advanced soft tissue sarcoma
Phase I/II
Metastatic or unresectable soft tissue sarcoma
recruiting
ADCLARA-01
ADCLARA-01: SOT106 (LRRC15 ADC) in LRRC15-positive osteosarcoma and STS
Phase I/II
LRRC15-positive osteosarcoma and soft tissue sarcoma
not_yet_recruiting
AGX101 (TM4SF1 ADC) in advanced solid tumours incl. angiosarcoma
Phase I
Advanced solid tumours incl. angiosarcoma
recruiting
AL58805 with AL8326, eribulin or fulvestrant in gynaecological cancers, STS and breast
Phase Ib/IIa
Soft tissue sarcoma, gynaecological cancers, breast cancer
not_yet_recruiting
APROMISS: catequentinib (AL3818) in ASPS, leiomyosarcoma and synovial sarcoma
Phase III
Alveolar soft part sarcoma, leiomyosarcoma, synovial sarcoma
recruiting
ATLAS: [225Ac]RTX-2358 (FAP radioligand) in relapsed or refractory soft tissue sarcoma
Phase I/II
Relapsed or refractory soft tissue sarcoma
recruiting
Afamitresgene autoleucel (MAGE-A4 TCR-T) Phase 1 dose escalation
Phase I
MAGE-A4-positive solid tumours incl. synovial sarcoma and MRCLS
active_not_recruiting
Catequentinib alone or with AL58805, temozolomide or CCNU (incl. STS cohorts)
Phase Ib/IIa
Soft tissue sarcoma, endometrial cancer, low-grade serous ovarian cancer, glioblastoma
not_yet_recruiting
HH2853-G101: EZH1/2 inhibitor in r/r NHL and advanced solid tumours incl. epithelioid sarcoma
Phase I/II
Epithelioid sarcoma; relapsed/refractory non-Hodgkin lymphoma
recruiting
Luca-1: SHY-ONC6 (19S proteasome ATPase inhibitor) in advanced solid tumours
Phase Ia/Ib
Advanced solid tumours (10 types) incl. soft tissue sarcoma
recruiting
PsiloStudy: A Phase 2 Single-site, Double-blind, Placebo-controlled, Randomized Trial With an Open-label Extension of Psilocybin Combined With Psychological Support (Psi-PS) for Military Veterans and First Responders With Co-occurring Alcohol Use Disorder and PTSD
Phase II
Co-occurring alcohol use disorder (AUD) and posttraumatic stress disorder (PTSD)
active
Hidden
QB46C-H07: intratumoural tigilanol tiglate in advanced soft tissue sarcoma
Phase IIa
Soft tissue sarcoma of the extremities and body wall
recruiting
SPEARHEAD-1
SPEARHEAD-1: afamitresgene autoleucel in advanced synovial sarcoma and MRCLS
Phase II
Advanced synovial sarcoma, myxoid/round cell liposarcoma
active_not_recruiting
SPEARHEAD-3
SPEARHEAD-3: afamitresgene autoleucel paediatric basket
Phase I/II
MAGE-A4-positive synovial sarcoma, MPNST, neuroblastoma, osteosarcoma (ages 2-17)
recruiting
ST-01156
ST-01156-101: RBM39 molecular glue degrader in advanced solid tumours incl. Ewing sarcoma
Phase I/Ib
Advanced solid tumours incl. Ewing sarcoma
recruiting
STC-15
STC-15 (METTL3 inhibitor) with toripalimab, and as monotherapy in selected sarcomas
Phase Ib/II
Dedifferentiated liposarcoma, uterine and non-uterine leiomyosarcoma; other advanced cancers
recruiting
Safety and Efficacy of the Xanomeline Transdermal Therapeutic System (TTS) in Patients with Mild to Moderate Alzheimers Disease.
Phase II
Mild to Moderate Alzheimers Disease
completed
Hidden
ZL-6201
ZL-6201-001: LRRC15 ADC in sarcoma and selected epithelial solid tumours
Phase Ia/Ib
Sarcoma and selected epithelial solid tumours
recruiting
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